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It also activates complement system by binding to LDL on atherosclerotic plaques and induces inflammation [15, 16]

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It was developed to solve some of the reported drawbacks of monohydrate supplementation, including: Bloating Cramping Water retention Conversion to creatinine (a byproduct associated with reduced absorption and potential digestive discomfort) One of the key challenges with creatine monohydrate is that it typically requires a loading phase of 10–15 grams per day for up to 10 days to saturate the muscles and start yielding benefits